Interventional neuroradiology

The interventional neuroradiology team led by Pr Charbel MOUNAYER is completely involved in the EMIS Research platform.
Our activities are based on preclinical research, education and trainings.
Our research scope includes ischemic and hemorrhagic neovascular diseases.
Our works are based on approved animal models with respect to ethical rules.
Our lab is equipped with the high-level Artis Icono angio-suite thanks to the research collaboration with Siemens Healthcare.
Our team is involved in a national labelled group XLIM CNR UMR 7252 with large expertise in histology, microscopy and pathology.
Our expertise provides the opportunity to conduct a scientific project from bench to bedside.
Our teaching is nationally recognized with unique french INR diploma with theoretical and practical teaching.
Our international communication is based on educational workshops and live congresses transmissions which attract physicians coming from all over the world.

The team

Professor Charbel MOUNAYER

Professor of the French universities
Head of Neuroradiology and Radiology departments in Dupuytren University Department, Limoges, France
Director of the French Interventional Neuroradiology Diploma
Member for the European Society of Neuroradiology (ESNR) Educational program
Member of the World Live Neuroconference (WLNC) organizing committee
Member of the CNRS XLIM UMR 7252 Research unit

Professor Aymeric ROUCHAUD

Professor of the French universities
Member of the Neuroradiology and Radiology departments in Dupuytren University Department, Limoges, France
Member of the CNRS XLIM UMR 7252 Research unit – Co-director of the Bio-Health Group
Co-Director of the French Interventional Neuroradiology Diploma
Member for the French Society of Neuroradiology (SFNR)
Associate Editor of the Journal of Neuroradiology
Research Chair of the Executive Committee of the European Society of Minimally Invasive Neurological Therapy (ESMINT)

Doctor Suzana SALEME

Interventional Neuroradiologist
Member of the Neuroradiology department in Dupuytren University Hospital, Limoges, France
Board member of the French Society of Neuroradiology
Member of the European Society of Neuroradiology

Jérémy MOUNIER

EMIS Project Manager
Design engineer
Health Biology Master – Biotechnologies, Genomics, Biotherapies – Limoges University

Dedicated team which daily follows research works and animal care

Laboratory

labo-1

Advanced imaging of flow-diverter stents

diapo-4

Brain AVM model and biological analysis

Diapo-10-768x439

Bio-optimization of intracranial devices

diapo-6-768x310

Stent retriever for ischemic stroke

Publications

• Multiphoton microscopy for pre-clinical evaluation of flow-diverter stents for treating aneurysms.
Bardet SM, Cortese J, Blanc R, Mounayer C, Rouchaud A.
J Neuroradiol. 2020 Mar 20:S0150-9861(20)30133-4. doi: 10.1016/j.neurad.2020.03.005. Online ahead of print. PMID: 32205257
• Intra-arterial in-situ bevacizumab injection effect on angiogenesis. Results on a swine angiogenesis model.
Papagiannaki C, Yardin C, Iosif C, Couquet C, Clarençon F, Mounayer C.
J Neuroradiol. 2020 Mar 14:S0150-9861(20)30130-9. doi: 10.1016/j.neurad.2020.03.003. Online ahead of print. PMID: 32184118
• Jailed Artery Ostia Modifications After Flow-Diverting Stent Deployment at Arterial Bifurcations: A Scanning Electron Microscopy Translational Study.
Iosif C, Ponsonnard S, Roussie A, Saleme S, Carles P, Ponomarjova S, Pedrolo-Silveira E, Mendes G, Waihrich E, Couquet C, Yardin C, Mounayer C.
Neurosurgery. 2016 Sep;79(3):473-80. doi: 10.1227/NEU.0000000000001311. PMID: 27337506
• Role of terminal and anastomotic circulation in the patency of arteries jailed by flow-diverting stents: from hemodynamic changes to ostia surface modifications.
Iosif C, Berg P, Ponsonnard S, Carles P, Saleme S, Ponomarjova S, Pedrolo-Silveira E, Mendes GAC, Waihrich E, Trolliard G, Couquet CY, Yardin C, Mounayer C.
J Neurosurg. 2017 May;126(5):1702-1713. doi: 10.3171/2016.2.JNS152120. Epub 2016 May 20.
PMID: 27203141
• Development of an angiogenesis animal model featuring brain arteriovenous malformation histological characteristics.
Papagiannaki C, Clarençon F, Ponsonnard S, Couquet C, Maizeroi-Eugène F, Bresson D, Yardin C, Mounayer C.
J Neurointerv Surg. 2017 Feb;9(2):204-210. doi: 10.1136/neurintsurg-2015-012173. Epub 2016 Mar 24.
PMID: 27013231
• Intravascular optical coherence tomography for the evaluation of arterial bifurcations covered by flow diverters.
Iosif C, Saleme S, Ponsonnard S, Carles P, Silveira EP, Waihrich E, Trolliard G, Yardin C, Mounayer C.
J Neurointerv Surg. 2016 Dec;8(12):1283-1287. doi: 10.1136/neurintsurg-2015-012084. Epub 2016 Jan 27.
PMID: 26819448
• Role of terminal and anastomotic circulation in the patency of arteries jailed by flow-diverting stents: animal flow model evaluation and preliminary results.
Iosif C, Berg P, Ponsonnard S, Carles P, Saleme S, Pedrolo-Silveira E, Mendes G, Waihrich E, Trolliard G, Couquet CY, Yardin C, Mounayer C.
J Neurosurg. 2016 Oct;125(4):898-908. doi: 10.3171/2015.8.JNS151296. Epub 2016 Jan 15.
PMID: 26771853
• Endothelialization of over- and undersized flow-diverter stents at covered vessel side branches: An in vivo and in silico study.
Berg P, Iosif C, Ponsonnard S, Yardin C, Janiga G, Mounayer C.
J Biomech. 2016 Jan 4;49(1):4-12. doi: 10.1016/j.jbiomech.2015.10.047. Epub 2015 Nov 7.
PMID: 26607220
• Scanning electron microscopy for flow-diverting stent research: technical tips and tricks.
Iosif C, Carles P, Trolliard G, Yardin C, Mounayer C.
Microscopy (Oxf). 2015 Jun;64(3):219-23. doi: 10.1093/jmicro/dfv009. Epub 2015 Feb 21.
PMID: 25713124
• A novel Swine model to evaluate arterial vessel injury after mechanical endovascular thrombectomy.
Gory B, Bresson D, Rouchaud A, Yardin C, Mounayer C.
Interv Neuroradiol. 2013 Jun;19(2):147-52. doi: 10.1177/159101991301900201. Epub 2013 May 21.
PMID: 23693036 Free PMC article.

• Histopathologic evaluation of arterial wall response to 5 neurovascular mechanical thrombectomy devices in a swine model.
Gory B, Bresson D, Kessler I, Perrin ML, Guillaudeau A, Durand K, Ponsonnard S, Couquet C, Yardin C, Mounayer C.
AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2192-8. doi: 10.3174/ajnr.A3531. Epub 2013 Mar 28.
PMID: 23538407
• Computational flow dynamics based on an intracranial aneurysm animal model.
Bresson D, Kharboutly Z, Mounayer C, Couquet CY, Gory B, Legallais C.
Comput Methods Biomech Biomed Engin. 2012;15 Suppl 1:46-8. doi: 10.1080/10255842.2012.713691.
PMID: 23009419 No abstract available.
• CD31 Mimetic Coating Enhances Flow Diverting Stent Integration into the Arterial Wall Promoting Aneurysm Healing.
Cortese J, Rasser C, Even G, Bardet SM, Choqueux C, Mesnier J, Perrin ML, Janot K, Caroff J, Nicoletti A, Michel JB, Spelle L, Caligiuri G, Rouchaud A.
Stroke. 2021 Jan;52(2):677-686. doi: 10.1161/STROKEAHA.120.030624. Epub 2021 Jan 8.
PMID: 33412905
• WEB Device Shape Changes in Elastase-Induced Aneurysms in Rabbits.
Ding Y, Dai D, Rouchaud A, Janot K, Asnafi S, Kallmes DF, Kadirvel R.
AJNR Am J Neuroradiol. 2021 Jan;42(2):334-339. doi: 10.3174/ajnr.A6899. Epub 2020 Dec 10.
PMID: 33303525
• Multiphoton microscopy for pre-clinical evaluation of flow-diverter stents for treating aneurysms.
Bardet SM, Cortese J, Blanc R, Mounayer C, Rouchaud A.
J Neuroradiol. 2020 Mar 20:S0150-9861(20)30133-4. doi: 10.1016/j.neurad.2020.03.005. Online ahead of print.
PMID: 32205257
• Autologous adipose-derived mesenchymal stem cells improve healing of coiled experimental saccular aneurysms: an angiographic and histopathological study.
Rouchaud A, Brinjikji W, Dai D, Ding YH, Gunderson T, Schroeder D, Spelle L, Kallmes DF, Kadirvel R.
J Neurointerv Surg. 2018 Jan;10(1):60-65. doi: 10.1136/neurintsurg-2016-012867. Epub 2017 Jan 11.
PMID: 28077523 Free PMC article.
• Wall Apposition Is a Key Factor for Aneurysm Occlusion after Flow Diversion: A Histologic Evaluation in 41 Rabbits.
Rouchaud A, Ramana C, Brinjikji W, Ding YH, Dai D, Gunderson T, Cebral J, Kallmes DF, Kadirvel R.
AJNR Am J Neuroradiol. 2016 Nov;37(11):2087-2091. doi: 10.3174/ajnr.A4848. Epub 2016 Jul 7.
PMID: 27390319 Free PMC article.
• Concomitant coiling reduces metalloproteinase levels in flow diverter-treated aneurysms but anti-inflammatory treatment has no effect.
Thielen E, McClure M, Rouchaud A, Ding YH, Dai D, Schroeder D, Cebral J, Kallmes DF, Kadirvel R.
J Neurointerv Surg. 2017 Mar;9(3):307-310. doi: 10.1136/neurintsurg-2015-012207. Epub 2016 Mar 14.
PMID: 26975840
• Differential Gene Expression in Coiled versus Flow-Diverter-Treated Aneurysms: RNA Sequencing Analysis in a Rabbit Aneurysm Model.
Rouchaud A, Johnson C, Thielen E, Schroeder D, Ding YH, Dai D, Brinjikji W, Cebral J, Kallmes DF, Kadirvel R.
AJNR Am J Neuroradiol. 2016 Jun;37(6):1114-21. doi: 10.3174/ajnr.A4648. Epub 2015 Dec 31.
PMID: 26721773 Free PMC article.
• Evaluation of the Angiographic Grading Scale in Aneurysms Treated with the WEB Device in 80 Rabbits: Correlation with Histologic Evaluation.
Rouchaud A, Brinjikji W, Ding YH, Dai D, Zhu YQ, Cloft HJ, Kallmes DF, Kadirvel R.
AJNR Am J Neuroradiol. 2016 Feb;37(2):324-9. doi: 10.3174/ajnr.A4527. Epub 2015 Sep 24.
PMID: 26405081
• Autologous mesenchymal stem cell endografting in experimental cerebrovascular aneurysms.
Rouchaud A, Journé C, Louedec L, Ollivier V, Derkaoui M, Michel JB, Mazighi M.
Neuroradiology. 2013 Jun;55(6):741-9. doi: 10.1007/s00234-013-1167-4. Epub 2013 Mar 21.
PMID: 23515660